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. 2011 Dec 23;3(12):82. doi: 10.1186/gm298

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Copyright ©2011 Schaeffeler et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Immunohistochemical staining of SLC22A1 protein in hepatocellular carcinoma and histological non-tumor adjacent tissue. (a) Expression of SLC22A1 is significantly decreased in hepatocellular carcinoma (HCC) versus adjacent non-tumor tissue (P < 0.0001) and individual paired results are given. For each patient, score values from both tissues are connected by a line. (b) Examples of different staining intensities (0 = negative, 1 = low, 2 = medium, 3 = high) in non-tumor as well as HCC tissues. SLC22A1 was present in all non-tumor tissues. (c) Exemplary weak immunohistochemical staining of SLC22A1 in two HCC samples is shown compared with strong staining in adjacent non-tumor liver tissue. In addition, representative examples of SLC22A3 staining in HCC tissue as well as in adjacent non-tumor liver tissue is shown. SLC22A1 and SLC22A3 are detected in the sinusoidal membrane of the hepatocytes (black arrows).