Tay et al. [2] |
Computational predictions combined with experimental analyses reveal protein-coding ceRNAs that act as trans-regulators of PTEN with similar tumor-suppressive properties |
Human prostate and colon cancer cell lines |
Karreth et al. [3] |
Transposon insertion within ZEB2 creates a new ceRNA pairing that decreases PTEN expression levels via crosstalk involving miR-181, miR-200b, miR-25 and miR-92a |
Human melanoma cell lines and a mouse model of melanoma |
Cesana et al. [4] |
Linc-MD1, a muscle-specific long noncoding RNA, regulates muscle differentiation by acting as a ceRNA that competes with MAML1 and MEF2C, transcripts encoding essential transcription factors involved in myogenic differentiation, for miR-133 and miR-135 |
Various mouse and human muscle cell types |
Sumazin et al. [5] |
Systematic analysis of genome-wide microRNA expression profiles reveals a ceRNA network that regulates key drivers of gliomagenesis through distinct oncogenic pathways and that determines tumor subtype formation |
Human glioblastoma cell lines |