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. 2011 Nov 7;12(11):R111. doi: 10.1186/gb-2011-12-11-r111

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Copyright ©2011 Cheng et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Distinctions between histone-sensitive and -insensitive TFs. (a) Target genes of histone-sensitive TFs are better predicted using intergenic or upstream histone modifications than are those of histone-insensitive TFs. (b) Histone-sensitive TFs have a smaller number of target genes in the regulatory network than histone-insensitive TFs. (c) Histone-sensitive TFs have a larger number of interaction partners in the protein-protein interaction (PPI) network. (d) Higher mRNA expression levels of histone-sensitive TFs.