Table 3.
Genes mutated in at least two S.pneumoniae penicillin resistant mutants
| S. pneumoniae strains | ||||
|---|---|---|---|---|
| Locus name | R6M1 | R6M2 | 1974M1 | 1974M2 |
| PBP1a | G544R | W411* | E248* | E158* |
| PBP2x | R384G,V518I, Q552E | Q281P, A369V, R384G, R426C, V518I | F388L, Q552E, V573L, V587L, G601V | A507V, P535L, Q552E |
| PBP2b | D415E, G665D | A395V, G435S, T451A | G435S, T451A | T431D, T451A, L492F, Q633E |
| Spr1178 | Q28* | Q28* | Q28* | Q28* |
| Spr1254 | G167S | T205I | WT | WT |
| Spr1888 | T728I | Q326* | WT | WT |
Mutations are shown as amino acid changes with their corresponding position in the protein. Asterisks indicate nonsense mutations. Mutations that are common in at least two strains are in bold.