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ICM cells are lost by apoptosis in Sin3a-null embryos. Examples of embryos recovered at 3.5 dpc (A) and 4.5 dpc (B) stained for Oct4 (red), activated Caspase-3 (green) or DAPI (blue). Quantitation of caspase positive staining in embryos recovered at 3.5 dpc (C) and 4.5 dpc (D). The graphs are derived from 38 wild-type or heterozygote embryos and 18 null embryos at 3.5 dpc (C), and 44 wild-type or heterozygotes and eight null 4.5 dpc embryos (D). Scale bar = 50 μm.
