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Effect of exogenous SIRT1 on the extracellular matrix metabolism of nucleus pulposus cells. mRNA expression of (a) aggrecan, (b) Sox9 and (c) collagen type 2 following treatment with recombinant human silent mating type information regulator 2 homolog 1 (rhSIRT1). Data were obtained from 11 patients (six lumbar spinal stenosis and lumbar disc herniation patients, and five idiopathic scoliosis patients). GAPDH, glyceraldehyde 3-phosphate dehydrogenase.
