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. 2011 Dec 16;13(6):R209. doi: 10.1186/ar3542

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Copyright ©2012 Kobie et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of effector and memory response following 2009-2010 TIV. (a) Trivalent influenza vaccine (TIV) IgG antibody-secreting cells (ASC) at day five to day seven vs. frequency of IgG TIV-specific memory B cells and (b) change in hemagglutination inhibition (HAI) titer as measured at one month. Fold change in IgD-CD27++CD38++ plasmablasts at (c) day five to day seven vs. frequency of IgG TIV-specific memory B cells and (d) change in HAI titer as measured at one month. Each symbol represents an individual study subject. Healthy controls (HC; n = 9 to 11), rheumatoid arthritis (RA; n = 3 to 5), RA+methotrexate (MTX; n = 3 to 4), RA+aTNF (n = 3 to 6). Spearman one-tailed correlation co-efficient (r) and significance (P) is indicated.