FIGURE 2.

Genes that undergo signal-responsive alternative splicing in JSL1 cells are enriched for activities required for T-cell function. (A) The 178 exons identified as signal-responsive in this study were analyzed by IPA (Ingenuity Systems; http://www.ingenuity.com) for functional categories. The categories graphed show above-threshold significance [−log(P-value) > 1.5] in enrichment relative to the 11,000 exons that were detectable in the RNA-seq analysis. The numbers above the bar graph represent the number of genes that score for each category. (B) Same as A, but genes were analyzed for their involvement in canonical signaling pathways.