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. 2012 May;18(5):973–991. doi: 10.1261/rna.030924.111

FIGURE 1.

FIGURE 1.

RNA construct design for the pseudoknot region of the S. cerevisiae TLC1. (A) Secondary structural representations of the pseudoknot region based on the original structural models (Chappell and Lundblad 2004; Dandjinou et al. 2004; Lin et al. 2004; Zappulla and Cech 2004). The helix V-forming sequence is indicated in green. (B) RNA constructs for the S. cerevisiae TLC1 pseduoknot region. Proposed Hoogsteen base triples (Shefer et al. 2007; Qiao and Cech 2008) are indicated on the PK sequence with blue dashed lines between loop 1 and stem 2. In both A and B, the sequences proposed to form the helix V hairpin are boxed in green. Nucleotides are numbered based on the complete S. cerevisiae TLC1 sequence in all figures.