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. 2012 Mar 15;9:53. doi: 10.1186/1742-2094-9-53

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Copyright ©2012 Tauchi et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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ADAMTS-4 expression and activity in the injured spinal cord of rats. ADAMTS-4 in the spinal cord tissue lysates was slightly increased after spinal cord injury compared with the sham-operated rats (Western blot analysis) (A). The proteolytic activity of ADAMTS-4 was significantly increased by about 1.4-fold in the rat spinal cord after injury (B). Enzymatic activities of tissue extracts of the spinal cord (1 cm around the lesion) were measured. *, P < 0.01. ADAMTS-4 mRNA was mainly expressed by astrocytes and microglia, but not neurons (C).