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Cleavage of CSPGs by ADAMTS-4. Cleavage of brevican (A), neurocan (B), and phosphacan (C) by human recombinant ADAMTS-4. CSPGs were incubated with the indicated enzymes and their degradation was estimated by Western blot analysis as described under the Methods. ADAMTS-4 degrades brevican, neurocan and phosphacan, whereas inactive ADAMTS-4, which had been heat-denatured, and ADAMTS-13 do not degrade these CSPGs. CSPGs, chondroitin sulfate proteoglycans.
