Table 4.
Accuracy of stroke volume and cardiac output changes after passive leg raising to predict fluid responsivenessa
| Criteria | Sensitivity | Specificity | LR+ | LR- | PPV | NPV |
|---|---|---|---|---|---|---|
| ΔPLRSV > 3% | 92% (64 to 100) | 67% (35 to 90) | 2.7 (1.8 to 4.3) | 0.12 (0.01 to 0.9) | 75% (48 to 93) | 89% (49 to 100) |
| ΔPLRSV > 5% | 92% (64 to 100) | 83% (52 to 98) | 5.5 (4.1 to 7.7) | 0.09 (0.01 to 0.9) | 86% (57 to 98) | 91% (59 to 100) |
| ΔPLRSV > 10% | 62% (32 to 86) | 92% (62 to 100) | 7.3 (4.7 to 11.7) | 0.42 (0.06 to 3.1) | 89% (52 to 100) | 69% (40 to 90) |
| ΔPLRSV > 15% | 39% (14 to 68) | 92% (62 to 100) | 4.6 (2.3 to 9.4) | 0.67 (0.1 to 4.6) | 83% 36 to 100) | 58% (34 to 80) |
| ΔPLRCO > 3% | 92% (64 to 100) | 67% (35 to 90) | 2.8 (1.8 to 4.3) | 0.12 (0.01 to 0.9) | 75% (48 to 93) | 89% (49 to 100) |
| ΔPLRCO > 5% | 85% (46 to 95) | 83% (52 to 98) | 5 (3.6 to 7.2) | 0.18 (0.03 to 1.1) | 85% (55 to 98) | 83% (52 to 98) |
| ΔPLRCO > 8% | 69% (39 to 91) | 83% (52 to 98) | 4.1 (2.7 to 6.5) | 0.37 (0.08 to 1.7) | 82% (48 to 98) | 71% (42 to 92) |
| ΔPLRCO > 12% | 54% (25 to 81) | 83% (52 to 98) | 3.2 (1.8 to 5.7) | 0.55 (0.1 to 2.2) | 78% (38 to 98) | 63% (35 to 85) |
aLR+, positive likelihood ratio; LR-, negative likelihood ratio; PPV; positive predictive value; NPV, negative predictive value; ΔPLRSV, stroke volume increase from baseline and after passive leg raising; ΔPLRCO, increase of cardiac output increase from baseline and after passive leg raising. Data are raw numbers and CI95 ranges.