Table 2.
Predictive value for 28-day mortality of ΔmHLA-DR and mHLA-DR
| Number of patients | Variables | Cutoff value | Sensitivity | Specificity | Positive predictive value | Negative predictive value | AUC | 95% CI | P value |
|---|---|---|---|---|---|---|---|---|---|
| 72 | ΔmHLA-DR3 | 4.8% | 89.0% | 93.7% | 70.9% | 98.0% | 0.919 ± 0.032 | 0.83-0.97 | < 0.001 |
| 66 | ΔmHLA-DR7 | 9.0% | 85.7% | 90.0% | 60.5% | 97.2% | 0.938 ± 0.030 | 0.851-0.982 | < 0.001 |
| 66 | ΔmHLA-DR7-3 | 3.5% | 66.1% | 80.0% | 37.1% | 92.9% | 0.729 ± 0.079 | 0.573-0.884 | 0.022 |
| 79 | mHLA-DR0 | 35.0% | 89.1% | 43.5% | 62.1% | 79.3% | 0.570 ± 0.070 | 0.453-0.682 | 0.319 |
| 72 | mHLA-DR3 | 39.5% | 91.1% | 37.5% | 54.6% | 83.6% | 0.629 ± 0.075 | 0.508-0.740 | 0.116 |
| 66 | mHLA-DR7 | 47.0% | 94.6% | 30.0% | 49.8% | 88.3% | 0.598 ± 0.094 | 0.460-0.708 | 0.376 |
ΔmHLA-DR3 and ΔmHLA-DR7 were defined as the value change in mHLA-DR on days 3 and 7 compared with that on day 0, and ΔmHLA-DR7-3 was defined as the value change in mHLA-DR on day 7 compared with that on day 3; mHLA-DR0, mHLA-DR3, and mHLA-DR7 were defined as the value of mHLA-DR on days 0, 3, and 7. AUC, area under the curve; CI, confidence interval; mHLA-DR, monocyte human leukocyte antigen-DR.