Table 2.
Patient characteristics before and after Genetic Matching for each subgroup
| Mean/percentagea DrotAA |
Mean/percentagea Control |
Percent standardized difference | |
|---|---|---|---|
| a. Subgroup with two organ systems failing | (n = 198) | (n = 630) | |
| Age (year)s | |||
| Unmatched | 57.58 | 63.04 | 26.49 |
| GenMatch | 61.76 | 61.82 | 0.37 |
| ICNARC model acute physiology score | |||
| Unmatched | 22.83 | 20.44 | 29.53 |
| GenMatch | 20.86 | 20.88 | 0.35 |
| Serious conditions in medical history, percentage | |||
| Cardiovascular | |||
| Unmatched | 1.01 | 1.75 | 5.40 |
| GenMatch | 1.57 | 1.57 | 0.00 |
| Respiratory | |||
| Unmatched | 4.55 | 4.13 | 1.67 |
| GenMatch | 2.78 | 3.87 | 2.15 |
| Renal | |||
| Unmatched | 2.02 | 3.81 | 9.17 |
| GenMatch | 1.09 | 3.14 | 5.06 |
| Liver | |||
| Unmatched | 1.52 | 1.27 | 1.69 |
| GenMatch | 1.33 | 1.33 | 0.00 |
| Immunosuppressed | |||
| Unmatched | 7.07 | 6.98 | 0.28 |
| GenMatch | 4.59 | 6.16 | 2.46 |
| ICNARC model predicted probability of acute hospital mortality | |||
| Unmatched | 0.42 | 0.39 | 10.76 |
| GenMatch | 0.39 | 0.39 | 0.37 |
| Organ systems failing in first 24 hoursb (percentage) - Cardiovascular/Respiratory | |||
| Unmatched | 76.26 | 66.19 | 18.61 |
| GenMatch | 75.60 | 69.69 | 4.70 |
| Mechanical ventilation (percentage) | |||
| Unmatched | 88.38 | 70.16 | 40.02 |
| GenMatch | 75.24 | 75.12 | 0.10 |
| b. Subgroup with three to five organ systems failing | (n = 878) | (n = 1,020) | |
| Age (years) | |||
| Unmatched | 58.96 | 65.16 | 32.32 |
| GenMatch | 62.46 | 62.47 | 0.00 |
| ICNARC model acute physiology score | |||
| Unmatched | 32.08 | 27.96 | 40.83 |
| GenMatch | 29.84 | 29.84 | 0.01 |
| Serious conditions in medical history (percentage) | |||
| Cardiovascular | |||
| Unmatched | 0.34 | 1.86 | 13.58 |
| GenMatch | 0.58 | 1.11 | 2.04 |
| Respiratory | |||
| Unmatched | 1.60 | 2.94 | 7.78 |
| GenMatch | 1.42 | 2.21 | 2.09 |
| Renal | |||
| Unmatched | 0.91 | 1.47 | 4.39 |
| GenMatch | 0.90 | 1.21 | 1.10 |
| Liver | |||
| Unmatched | 0.68 | 1.77 | 8.70 |
| GenMatch | 1.16 | 1.16 | 0.00 |
| Immunosuppressed | |||
| Unmatched | 7.29 | 12.75 | 15.55 |
| GenMatch | 6.11 | 9.80 | 4.83 |
| ICNARC model predicted probability of acute hospital mortality | |||
| Unmatched | 0.64 | 0.58 | 20.12 |
| GenMatch | 0.61 | 0.61 | 0.00 |
| Number of organ systems failing during first 24 hours of stay in critical care (percentage) | |||
| Three | |||
| Unmatched | 49.09 | 62.94 | 22.88 |
| GenMatch | 54.69 | 56.74 | 1.46 |
| Four | |||
| Unmatched | 41.12 | 29.31 | 20.07 |
| GenMatch | 36.57 | 34.14 | 1.79 |
| Five | |||
| Unmatched | 9.80 | 7.75 | 5.82 |
| GenMatch | 8.75 | 9.12 | 0.46 |
| Organ systems failing during first 24 hours of stay in critical careb (percentage) | |||
| Cardiovascular/Respiratory/Acidosis | |||
| Unmatched | 40.77 | 46.08 | 8.77 |
| GenMatch | 44.10 | 43.99 | 0.08 |
| Cardiovascular/Respiratory/Renal/Acidosis | |||
| Unmatched | 31.09 | 19.90 | 20.64 |
| GenMatch | 25.76 | 24.97 | 0.64 |
| Mechanical ventilation on admission or during first 24 hours of stay in critical care (percentage) | |||
| Unmatched | 93.39 | 78.53 | 38.90 |
| GenMatch | 85.51 | 85.51 | 0.00 |
a Mean reported for continuous variable and percentage for categorical variable.
bFor the types of organ failure, results are presented for the most prevalent type for each number of organ failures; results for other types of organ failure are presented in Additional file 1. DrotAA, Drotrecogin alfa (activated); GenMatch, Genetic Matching; ICNARC, Intensive Care National Audit & Research Centre.