Table 2. IC₅₀ values for TAE684 and HG-7-27-01 inhibition of tubulin phosphorylation by recombinant SH2-kinase vs. full-length c-Fes-Flag or c-Fes-L145P-Flag.

IC₅₀ values as well as 95% confidence intervals (CI) from three independent determinations are shown. The concentration-response curves used to generate these values are shown in Figure 4B.

	TAE684		HG-7-27-01
Kinase	IC₅₀ (nM)	95% CI (nM)	IC₅₀ (nM)	95% CI (nM)
SH2-KD	45.8	41.3 – 50.7	494.9	385.4 – 636.5
Fes-Flag	15.0	10.1 – 22.1	1297	517.2 – 3252
Fes-L145P-Flag	29.7	11.6 – 76.0	5243	3068 – 8961

Table 2. IC50 values for TAE684 and HG-7-27-01 inhibition of tubulin phosphorylation by recombinant SH2-kinase vs. full-length c-Fes-Flag or c-Fes-L145P-Flag.

Table 2. IC₅₀ values for TAE684 and HG-7-27-01 inhibition of tubulin phosphorylation by recombinant SH2-kinase vs. full-length c-Fes-Flag or c-Fes-L145P-Flag.