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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Hematol Oncol Clin North Am. 2012 Feb 28;26(3):527–542. doi: 10.1016/j.hoc.2012.01.004

Figure 1. Components of the IGF axis.

Figure 1

The IGF axis is composed by two IGF ligands, IGF-I and IGF-II. They bind one of the different IGF binding proteins, (BPs). The majority of circulating IGF is bound to IGFBP-3 and a molecule called acid labile subunit. The different combinations of receptors in the axis bind to IGF-I, IGF-II and insulin with different affinities, as represented by the large or small size of the ligand.