Table 4.

Adjusted⁵ Odds Ratios (ORs) by NPI² Domain

	CIND1 vs. Normal		Dementia vs. CIND1		Dementia vs. Normal		aMCI3 vs. Other4
NPI2 Domain	OR (95% CI)	P Value	OR (95% CI)	P Value	OR (95% CI)	P Value	OR (95% CI)	P Value
Delusions	N/A^	−	9.5 (3.0–30.7)	<0.001	N/A^	−	0.8 (0.05–10.7)	0.842
Hallucinations	3.9 (0.4–38.1)	0.239	4.6 (1.4–14.6)	0.01	38.9 (4.5–334.6)	0.001	N/A^	−
Agitation/Aggression	3.5 (1.1–11.3)	0.038	2.0 (0.9–4.5)	0.081	12.7 (3.6–44.3)	<0.001	0.7 (0.2–2.4)	0.631
Depression/dysphoria	3.8 (2.3–6.4)	<0.001	1.5 (0.9–2.5)	0.117	8.7 (4.4–17.1)	<0.001	0.8 (0.5–1.5)	0.595
Anxiety	5.8 (2.0–16.3)	0.001	1.9 (0.9–4.1)	0.103	11.1 (3.4–36.5)	<0.001	1.6 (0.6–4.6)	0.388
Elation/euphoria	N/A^	−	1.5 (0.1–42.6)	0.811	N/A^	−	N/A^	−
Apathy/indifference	10.0 (3.3–29.7)	<0.001	2.0 (1.1–3.8)	0.03	28.1 (8.6–91.0)	<0.001	1.2 (0.5–3.2)	0.708
Disinhibition	2.8 (0.3–29.9)	0.398	4.2 (1.1–16.6)	0.037	22.1 (2.3–212.0)	0.007	N/A^	−
Irritability/lability	3.5 (1.9–6.5)	<0.001	1.9 (1.0–3.5)	0.034	11.8 (5.1–27.2)	<0.001	0.7 (0.3–1.5)	0.375
Motor Disturbance	N/A^	−	5.5 (0.5–60.1)	0.16	N/A^	−	N/A^	−
Nighttime Behaviors	1.1 (0.6–1.9)	0.746	1.3 (0.6–2.9)	0.453	1.2 (0.5–3.1)	0.72	1.5 (0.7–3.6)	0.316
Appetite/eating	5.6 (2.0–15.9)	0.001	2.3 (1.1–4.9)	0.029	12.0 (3.7–38.6)	<0.001	0.7 (0.3–2.2)	0.604

¹CIND: cognitive impairment, no dementia;

²NPI: neuropsychiatric inventory;

³aMCI: amnestic-MCI;

⁴Other: CIND types other then aMCI;

⁵ORs were adjusted for age, education, ApoE ε4 status, CDR, and 3MS;

^{^}A value of “N/A” listed next to an NPI domain indicates that one of the groups in that comparison had a value of “0.”