Figure 3. Cellular toxicity of thiadiazolidinedione compounds.
Four different cervical cancer cells lines: SiHa, TC-1, HeLa and C-33A and one non-cervical cancer cell line, HCT116, were employed for these studies. 2-fold compound dilutions starting at 100 µM down to 3.125 µM for the thiadiazolidinediones and starting at 2 µM to 4 nM for staurosporine were incubated for 48 hours with cells before the addition of MTS reagent. After 1–2 hours of incubation with reagent, the absorbance at 490 nm was determined. The percent growth was determined by dividing by the growth in the presence of DMSO control. See also Table S2.