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. Author manuscript; available in PMC: 2013 Apr 20.
Published in final edited form as: Chem Biol. 2012 Apr 20;19(4):518–528. doi: 10.1016/j.chembiol.2012.03.007

Figure 4. Effects on the cell cycle and apoptosis by the thiadiazolidinediones 478166 and 478168, an inactive analog, and staurosporine.

Figure 4

To determine any effect on cell cycle or apoptosis, SiHa cells were treated with DMSO or 10 µM of compounds 478166, 478168, 44234, or 2 µM staurosporine for 48 hours. After 48 hours, cells were harvested, stained with propidium iodide, and DNA content was analyzed by flow cytometry. The percent of cells in G0/G1, G2/M, S, or apoptotic were determined by the areas under the curves represented by B, C, D, and E, respectively.