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. Author manuscript; available in PMC: 2013 Apr 20.
Published in final edited form as: Chem Biol. 2012 Apr 20;19(4):518–528. doi: 10.1016/j.chembiol.2012.03.007

Table 2.

IC50 values for compounds to inhibit HPV-E7-mediated disruption of pRb/E2F complexes and for disrupting pRb/viral oncoprotein complexes

graphic file with name nihms366973t1.jpg 16E7
(500nM)
(µM)		 1AE7
(500nM)
(µM)		 E1A
(100nM)
(µM)		 KD (µM)
(to pRb)		 Structure ID
pRb/E2F 7.6 ± 1.2 10.6 ± 1.3 2.8 ± 2.2 graphic file with name nihms366973t2.jpg LCGC12 478081
pRb 11.2 ± 1.3 7.9 ± 2.1 5.0 ± 1.8 0.165 ± 0.052
pRb/E2F 2.2 ± 1.6 3.5 ± 1.6 0.64 ± 2.3 graphic file with name nihms366973t3.jpg LCGC12 478165
pRb 0.57 ± 1.2 3.0 ± 2.3 2.6 ± 1.3 0.104 ± 0.025
pRb/E2F 1.9 ± 1.3 4.5 ± 1.7 0.24 ± 2.0 graphic file with name nihms366973t4.jpg LCGC12 478166
pRb 0.50 ± 1.5 3.4 ± 2.0 1.0 ± 2.1 0.106 ± 0.034
pRb/E2F 3.2 ± 1.3 5.5 ± 1.7 1.3 ± 2.2 graphic file with name nihms366973t5.jpg LCGC12 478168
pRb 4.5 ± 1.5 4.7 ± 2.1 3.8 ± 1.5 0.187 ± 0.022
pRb/E2F 4.6 ± 1.3 5.5 ± 1.5 1.1 ± 2.5 graphic file with name nihms366973t6.jpg LCGC12 478337
pRb 3.2 ± 1.3 5.5 ± 2.7 3.5 ± 1.7 0.210 ± 0.051
pRb/E2F 2.3 ± 1.6 3.3 ± 1.6 1.7 ± 2.7 graphic file with name nihms366973t7.jpg LCGC12 478419
pRb 0.40 ± 1.4 1.3 ± 1.3 7.7 ± 1.7 0.381 ± 0.031
pRb/E2F 0.34 ± 1.9 3.5 ± 1.7 3.2 ± 2.7 graphic file with name nihms366973t8.jpg LCGC10 478726
pRb 0.29 ± 1.7 4.0 ± 2.5 2.8 ± 2.1 0.815 ± 0.070
*

all values indicated are from experiments that were done in triplicate.