Table 1. Transcription factor mutants defective in hyphal maintenance in rapamycin.
Gene name | Description* | Germ tube formation in YPD | Hyphal elongation in YPD+rapamycin |
Wild type | + + + + + | + + + + + | |
NTO1 | Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3 | + + + + + | + + + |
GIS2 | Putative transcription factor; expression is increased in high iron and reduced upon yeast-hyphal switch; null mutant exhibits sensitivity to sorbitol, 5-fluorocytosine, and cold temperatures | + + + + + | + + + |
ASH1 | GATA-like transcription factor; localizes to nuclei of daughter cells and hyphal tip cells; mRNA localization is mediated by binding to She3p; required for wild-type virulence and filamentous growth | + + + + + | + + + |
BRG1 | Putative DNA-binding transcription factor; similar to S. cerevisiae Gat2p; transposon mutation affects filamentous growth | + + + + + | + |
ASG1 | Gal4p family zinc-finger transcription factor with similarity to S. cerevisiae Asg1p | + + + + + | + + |
ROB1 | Putative protein of unknown function; null mutant displays abnormal colony morphology and invasive growth; caspofungin repressed | + + + | + |
AHR1 | Zinc-finger transcription factor involved in regulation of adhesion genes; involved in white-opaque switch; forms complex with Mcm1p; null mutant displays sensitivity to 5-fluorocytosine and to lithium chloride | + + | + |
BCR1 | C2H2 zinc finger transcription factor required for wild-type biofilm formation; mutation affects filamentous growth; regulates cell-surface-associated genes; filament induced; Tup1p-, Tec1p-, Mnl1p-regulated; mRNA binds to She3p | + + + | + + |
*: All descriptions are from the Candida Genome Database. + indicates levels of filamentation.