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. 2012 Apr 19;7(4):e35539. doi: 10.1371/journal.pone.0035539

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Thomas et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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H&E-stained sections of control (A–C) and Alk2/Gata5-Cre mutant (D–F) at three different levels showing perimembranous VSD in mutant (black arrow in E) but not control. Right (G–J) and left (K–N) atrioventricular valves from control (G, H, K, L) and Alk2/Gata5-Cre mutant (I, J, M, N) samples. Representative immunostained sections from two levels from each heart are shown: periostin (green), MF20 (red). Postero-inferior leaflet (G–J) shorter with less periostin-positive tissue (green) in mutant (I, J) than control (G, H) (arrows) and more myocardium (red: arrowheads). Control (K, L) and mutant (M, N) left AV valve leaflets do not differ (arrows, arrowheads). AVJ posterior side of atrioventricular junction; IVS muscular part of ventricular septum; LA, left atrium; LV, left ventricle; LVO, outlet part of LV leading to aortic valve; RA, right atrium; RV, right ventricle.