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. 2012 Apr 19;7(4):e35130. doi: 10.1371/journal.pone.0035130

Figure 4. Inhibition of Sp dependent transcription by MTM-SDK and MTM-SK in tumor xenografts.

Figure 4

Mice (n = 4/group) with subcutaneous tumors were treated with a single IV injection of MTM-SDK, MTM-SK or sterile saline solution. Doses of MTM-SK and MTM-SDK were 8 mg/kg and 1.2 mg/kg, respectively. Tumors were harvested 1, 3 and 7 days after drug injection. Gene expression was assessed by qRT-PCR. Data represent mean ± SD of the transcript level normalized to B2M RNA and are presented as percentage of expression compared to control mice receiving sterile saline solution. *, P<0.01; **, P<0.001.