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Mice with subcutaneous tumors were treated with the indicated doses of MTM-SDK, MTM-SK or sterile saline solution (control) given by IP injections twice a week for five weeks (q3d×10). Tumor volume (A) and body weight (B) were measured twice a week. Results are expressed as mean ± SD of the tumor volume in each group. Arrows indicate start and end of the treatment. **, P<0.001.
