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. 2012 Apr 20;7(4):e35675. doi: 10.1371/journal.pone.0035675

Figure 2. Inhibition of surfactant function exacerbates pulmonary inflammation in response to zymosan particles.

Figure 2

(A) Pulmonary histology following intra-tracheal administration of zymosan, zymosan plus EDTA, PBS or EDTA, stained with haematoxylin and eosin (H&E) or for the presence of zymosan (α-zymosan), as indicated. (B) Quantitation of neutrophil (CD11b+GR-1+) cells in the lungs of infected mice. (C) Production of selected cytokines and chemokines in the lungs of individual mice following intra-tracheal challenge with zymosan or zymosan plus EDTA. The data shown are representative of at least two independent experiments, except for (B) which is a single experiment. *p<0.05.