Figure 5. The induction of inflammatory responses to Aspergillus resting conidia is delayed and occurs after particle uptake.

(A) The production of TNF over time following the infection of thioglycollate-elicited or alveolar macrophages with zymosan particles (black circles) or resting Aspergillus conidia (black squares), as indicated. The data shown are the mean ± SD, and are representative of at least two independent experiments. *p<0.05. (B) Orthogonal confocal projections of CFSE-labelled thioglycollate-elicited macrophages (green) 3 and 6 hr after the uptake of resting Aspergillus conidia (labelled with calcofluor, red).