Table 1. Summary of the COG classification of the identified and predicted M. fermentans M64 ORFs.

COG ID	Description	No. of identified ORFsa	No. of predicted ORFsb	Identification ratio
INFORMATION STORAGE AND PROCESSING
J	Translation, ribosomal structure and biogenesis	33	102	32.35%
K	Transcription	8	31	25.81%
L	DNA replication, recombination and repair	11	93	11.83%
CELLULAR PROCESSES
D	Cell division and chromosome partitioning	3	13	23.08%
V	Defense mechanisms	1	23	4.35%
T	Signal transduction mechanisms	0	7	0.00%
M	Cell envelope biogenesis, outer membrane	4	18	22.22%
U	Intracellular trafficking, secretion, and vesicular transport	1	23	4.35%
O	Posttranslational modification, protein turnover, chaperones	8	17	47.06%
METABOLISM
C	Energy production and conversion	7	22	31.82%
G	Carbohydrate transport and metabolism	19	62	30.65%
E	Amino acid transport and metabolism	7	30	23.33%
F	Nucleotide transport and metabolism	12	23	52.17%
H	Coenzyme metabolism	3	12	25.00%
I	Lipid metabolism	1	9	11.11%
P	Inorganic ion transport and metabolism	2	28	7.14%
Q	Secondary metabolites biosynthesis, transport and catabolism	1	3	33.33%
POORLY CHARACTERIZED
R	General function prediction only	16	67	23.88%
S	Function unknown	3	43	6.98%
OTHERS
COG-absent		46		10.00%

^aThe COG assignment of each identified protein can be found in Table S2.

^bThe COG assignment of each predicted protein can be found in Table S4.