Figure 3. Screening of TGR inhibitors.

The % of inhibition of TR activity of E. granulosus TGR for each compound is shown (compound structures can be found in Table S1). The screening was carried out with 10 µM inhibitors, except for those marked with an asterisk, which were assayed at 1 µM (these compounds showed non-constant baselines at 10 µM in control experiments without enzyme). A 1 nM TGR was used in all cases. a. Oxadiazole N-oxides, b. Benzofuroxans, c. Thiadiazoles, d. Various compound families: quinoxalines (61, 62 and 65), nitrooxy (64) and oxathiazole (63).