Table 1. Quantitative analysis of the expression of scaffolding proteins and adhesion molecules at excitatory synapses in controls and after partial status epilepticus.
weeks | group | CD spine iML | CD spine oML | CD shaft iML | CD shaft oML | CS iML | CS oML | |
PSD-95 | 3 | c | 0.01±0.005 | 0.01±0.009 | 0.02±0.007 | 0.01±0.009 | 0.18±0.03 | 0.17±0.01 |
pSE | 0.01±0.002 | 0.02±0.007 | 0.02±0.007 | 0.02±0.007 | 0.16±0.02 | 0.20±0.05 | ||
6 | c | 0.06±0.02 | 0.09±0.03 | 0.05±0.02 | 0.04±0.02 | 0.11±0.01 | 0.12±0.01 | |
pSE | 0.03±0.01 | 0.03±0.004 | 0.09±0.03 | 0.05±0.01 | 0.12±0.006 | 0.11±0.01 | ||
NL-1 | 1 | c | 0 | - | 0.003±0.001 | - | 0.08±0.008 | - |
pSE | 0.001±0.001 | - | 0.005±0.002 | - | 0.12±0.01 | - | ||
3 | c | 0.02±0.007 | 0.01±0.004 | 0.04±0.01 | 0.04±0.006 | 0.09±0.003 | 0.11±0.009 | |
pSE | 0.01±0.006 | 0.006±0.003 | 0.06±0.02 | 0.03±0.01 | 0.09±0.004 | 0.09±0.007 | ||
6 | c | 0.02±0.01 | 0.03±0.008 | 0.12±0.02 | 0.03±0.008 | 0.09±0.008 | 0.09±0.003 | |
pSE | 0.03±0.01 | 0.03±0.008 | 0.13±0.02 | 0.03±0.008 | 0.10±0.03 | 0.10±0.006 | ||
N-cadherin | 1 | c | 0.006±0.006 | - | 0.002±0.002 | - | 0.17±0.17 | - |
pSE | 0.004±0.004 | - | 0.003±0.003 | - | 0.21±0.05 | - | ||
3 | c | 0.01±0.004 | 0.02±0.01 | 0.007±0.004 | 0.004±0.002 | 0.14±0.04 | 0.15±0.01 | |
pSE | 0.01±0.004 | 0.002±0.002 | 0.004±0.002 | 0.006±0.003 | 0.20±0.04 | 0.14±0.006 | ||
6 | c | 0.006±0.002 | 0.02±0.007 | 0 | 0.004±0.003 | 0.14±0.03 | 0.20±0.01 | |
pSE | 0.006±0.002 | 0.003±0.002 | 0.004±0.004 | 0.004±0.003 | 0.17±0.03 | 0.12±0.03 |
Scaffolding protein (PSD-95) and adhesion molecule (NL-1 and N-cadherin) expression at excitatory synapses on GPF+ dendrites of one, three, and six-week-old adult-born neurons, formed after pSE and in controls (c). Cluster density (CD; clusters/µm) is given for iML and oML, on dendritic spines and shafts. Cluster size (CS; µm2) is given for iML and oML, dendritic shafts and spines pooled. Values are mean ± SEM.