FIG. 3.

Representative local cerebral blood flow (LCBF) parametric maps from an injured untreated (A) and an acetazolamide (ACZ)-treated rat (B) at 3 h after injury, and (C) bar graphs of quantified contralateral and ipsilateral LCBF values (as percentages of the corresponding sham control region of interest [ROI] values) in untreated-injured (open bars), and ACZ-treated rats (solid bars), at 3 h post-trauma in grey and white matter (shaded area) brain regions. Administration of ACZ resulted in a global increase in LCBF that was maintained in both grey and white matter regions until 3 h post-injury (A versus B). LCBF values were significantly increased bilaterally in most regions of the brain compared to untreated, injured rats, such that values were similar to or above those in sham-injured rats (horizontal line). Data are plotted as means±standard error of the mean; *p<0.05, **p<0.01 corrected for multiple comparisons; Core, contusion core; Marg, pericontusion margin; Cing, cingulum; Thal, thalamus; CC, corpus callosum; EC, external capsule; IC, internal capsule; DG, dentate gyrus). Color image is available online at www.liebertonline.com/neu