FIG. 5.

Representative parametric maps from an injured, untreated (A) and acetazolamide (ACZ)-treated rat (B) at 3 h after trauma for the calculated ratio of LCMRglc: LCBF. The ratio between flow and metabolism was decreased globally by ACZ (B), and this extended to the pericontusion margin (arrows). (C) Bar graph demonstrating ipsilateral LCMRglc:LCBF ratio values (as percentages of the corresponding sham-control region-of-interest [ROI] data) in untreated-injured (open bars) and ACZ-treated rats (solid bars) in grey and white matter (shaded area) brain regions. ACZ significantly reduced the ratios in most regions of the ipsilateral hemisphere, including the pericontusion margin. Data are plotted as means±standard error of the mean; the horizontal line represents sham-injured values. (Core, contusion core; Marg, pericontusion margin; Cing, cingulum; Thal, thalamus; CC, corpus callosum; EC, external capsule; IC, internal capsule; DG, dentate gyrus; LCMRglc:LCBF, local cerebral metabolic rate for glucose:local cerebral blood flow ratio). Color image is available online at www.liebertonline.com/neu