Table 2.

Functional Pathway Analysis Using DIANA mirPath Software

S#	KEGG Pathway-Target Scan	No. of Genes (Union)	-In (p-value) Union	KEGG Pathway microT4	No. of Genes (Union)	-In (p-value) Union	KEGG Pathway PicTar	No. of Genes (Union)	-In (p-value) Union	KEGG Pathway-Target Scan-PicTar-microT4	No. of Genes (Union)	-In (p-value) Union
1	Axon guidance	63	29.59	Axon guidance	67	38.55	Axon guidance	44	24.8	Axon guidance	85	44.34
2	Focal adhesion	84	28.9	MAPK signaling pathway	106	33.93	MAPK signaling pathway	69	21.6	Wnt signaling pathway	86	33.73
3	MAPK signaling pathway	99	23.59	Focal adhesion	84	30.96	Wnt signaling pathway	45	20.33	Focal adhesion	105	31.86
4	Glioma	35	21.89	Renal cell carcinoma	40	27.8	Colorectal cancer	27	12.72	MAPK signaling pathway	128	29.14
5	TGF-β signaling pathway	43	19.15	Glioma	36	25.13	Melanogenesis	29	11.46	Colorectal cancer	54	24.96
6	Chronic myeloid leukemia	38	18.55	Regulation of actin cytoskeleton	84	24.11	TGF-β signaling pathway	27	11.4	Regulation of actin cytoskeleton	106	24.86
7	Renal cell carcinoma	35	17.16	Wnt signaling pathway	63	23.1	mTOR signaling pathway	18	10.1	Melanogenesis	58	22.01
8	Wnt signaling pathway	59	16.67	Chronic myeloid leukemia	39	21.39	Insulin signaling pathway	35	9.14	ErbB signaling pathway	52	21.07
9	Adherens junction	36	16.47	Colorectal cancer	42	20.99	Renal cell carcinoma	21	8.77	Glioma	41	20.46
10	Regulation of actin cytoskeleton	78	16.13	ErbB signaling pathway	41	18.79	ErbB signaling pathway	24	8.26	Chronic myeloid leukemia	47	20.37

For all the significantly modulated microRNAs (miRNAs), the DNA intelligent analysis (DIANA) mirPath algorithm combined with miRNA target prediction web tools of DIANA microT 4.0, TargetScan 5, and PicTar was performed. The results represented here indicate the top predicted biological functions of modulated miRNAs.

KEGG, Kyoto Encyclopedia of Genes and Genomes.