Table 2.
S# | KEGG Pathway-Target Scan | No. of Genes (Union) | -In (p-value) Union | KEGG Pathway microT4 | No. of Genes (Union) | -In (p-value) Union | KEGG Pathway PicTar | No. of Genes (Union) | -In (p-value) Union | KEGG Pathway-Target Scan-PicTar-microT4 | No. of Genes (Union) | -In (p-value) Union |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Axon guidance | 63 | 29.59 | Axon guidance | 67 | 38.55 | Axon guidance | 44 | 24.8 | Axon guidance | 85 | 44.34 |
2 | Focal adhesion | 84 | 28.9 | MAPK signaling pathway | 106 | 33.93 | MAPK signaling pathway | 69 | 21.6 | Wnt signaling pathway | 86 | 33.73 |
3 | MAPK signaling pathway | 99 | 23.59 | Focal adhesion | 84 | 30.96 | Wnt signaling pathway | 45 | 20.33 | Focal adhesion | 105 | 31.86 |
4 | Glioma | 35 | 21.89 | Renal cell carcinoma | 40 | 27.8 | Colorectal cancer | 27 | 12.72 | MAPK signaling pathway | 128 | 29.14 |
5 | TGF-β signaling pathway | 43 | 19.15 | Glioma | 36 | 25.13 | Melanogenesis | 29 | 11.46 | Colorectal cancer | 54 | 24.96 |
6 | Chronic myeloid leukemia | 38 | 18.55 | Regulation of actin cytoskeleton | 84 | 24.11 | TGF-β signaling pathway | 27 | 11.4 | Regulation of actin cytoskeleton | 106 | 24.86 |
7 | Renal cell carcinoma | 35 | 17.16 | Wnt signaling pathway | 63 | 23.1 | mTOR signaling pathway | 18 | 10.1 | Melanogenesis | 58 | 22.01 |
8 | Wnt signaling pathway | 59 | 16.67 | Chronic myeloid leukemia | 39 | 21.39 | Insulin signaling pathway | 35 | 9.14 | ErbB signaling pathway | 52 | 21.07 |
9 | Adherens junction | 36 | 16.47 | Colorectal cancer | 42 | 20.99 | Renal cell carcinoma | 21 | 8.77 | Glioma | 41 | 20.46 |
10 | Regulation of actin cytoskeleton | 78 | 16.13 | ErbB signaling pathway | 41 | 18.79 | ErbB signaling pathway | 24 | 8.26 | Chronic myeloid leukemia | 47 | 20.37 |
For all the significantly modulated microRNAs (miRNAs), the DNA intelligent analysis (DIANA) mirPath algorithm combined with miRNA target prediction web tools of DIANA microT 4.0, TargetScan 5, and PicTar was performed. The results represented here indicate the top predicted biological functions of modulated miRNAs.
KEGG, Kyoto Encyclopedia of Genes and Genomes.