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Cells from Atg5+/+ and Atg5−/− cell lines were treated with 10 μM CBZ for 1 hour prior to 6 Gy irradiation, harvested at different time points and antioxidant levels measured. Baseline antioxidants remained higher in autophagy-proficient Atg5+/+ cells. CBZ-treated Atg5+/+ cells had an increase in antioxidants at 10 minutes, peaking at 60 minutes after irradiation.
