Table VI.

Effect of carbamazepine (CBZ) on antioxidant stores in irradiated Atg5^+/+ compared to Atg5^−/− (WT) cell lines.

Cell Line	Total antioxidants (Trolox equivalents)				GSH (μM)
	0 Gy		24 h after 4 Gy		0 Gy		6 h after 6 Gy
	0 μM CBZ	10 μM CBZ	0 μM CBZ	10 μM CBZ	0 μM CBZ	10 μM CBZ	0 μM CBZ	10 μM CBZ
WT 1			0.026	0.039		0.217	2.111	<0.010
WT 3			0.064	0.050			0.067	<0.010
KO 2	0.49	0.67	0.039	0.043	<0.010	<0.010	<0.010	<0.010
KO 4			0.042	0.133			<0.010	<0.010

Clonal cell lines of Atg5^+/+ (WT1 and 3) and Atg5^−/− (KO2 and 4) were irradiated to doses from 0, 4 or 6 Gy as described in the methods. Total antioxidants (Trolox units) and levels of glutathione (GSH) were measured using a commercial kit at 24 hours following 4 Gy or 6 hours after irradiation of 6 Gy, respectively.