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Cox proportional hazards model for disease-free survival comparing ESR1-deleted and ESR1-amplified cohorts (aberrant cohorts) versus the ESR1-normal cohort overall and for subgroups defined by HER2 status and Ki-67 labeling index category. Hazard ratio values <1.0 indicate a better outcome for the aberrant (either deleted or amplified) compared with ESR1 normal. HER2, human epidermal growth factor receptor-2.
