Table 2.

Hypoxia induced genes are overexpressed in human brain tumours.

Gene	Brain tumour type	Upregulation fold/normal	P Value	Patients' number	Study/year [REF]
SOX4	Oligodendroglioma	27.195	P = 7.16E − 22	50	Nutt Brain/2006 [36]
	Anaplastic astrocytoma	22.784	P = 1.96E − 13	19
	Glioblastoma	4.149	P = 1.06E − 21	81
	Diffuse astrocytoma	9.109	P = 0.007	7
	Glioblastoma	3.084	P = 8.51E − 8	27	Shai Brain/2003 [37]
	Astrocytoma	6.100	P = 1.65E − 5	45	Rickman Brain/2001 [38]
	Anaplastic oligoastrocytoma	17.598	P = 6.05E − 5	4	French Brain/2005 [27]
	Anaplastic oligodendroglioma	2.790	P = 4.62E − 8	23
	Glioblastoma	6.140	P = 2.76E − 9	27	Bredel Brain 2/2005 [39]
	Oligodendroglioma	12.935	P = 2.22E − 4	5
	Anaplastic oligodendroglioma	15.078	P = 0.002	3
	Anaplastic oligoastrocytoma	8.939	P = 0.006	6
	Glioblastoma	4.579	P = 2.20E − 4	29	Liang Brain/2005 [40]
	Oligoastrocytoma	7.482	P = 0.009	3
	Pilocytic astrocytoma	3.445	P = 0.008	8	Gutmann Brain/2002 [41]
SOX9	Malignant glioma	4.330	P = 9.30E − 6	10	Pomeroy Brain/2002 [28]
	Atypical teratoid/rhabdoid tumour	3.668	P = 0.007	5
	Desmoplastic medulloblastoma	2.599	P = 0.002	14
	Anaplastic oligoastrocytoma	4.005	P = 0.009	23	French Brain/2005 [27]
	Anaplastic oligodendroglioma	2.731	P = 3.03E − 4	4
	Glioblastoma	2.566	P = 2.84E − 5	27	Shai Brain/2003 [37]
	Anaplastic astrocytoma	2.340	P = 2.79E − 7	19	Sun Brain/2006 [36]
	Glioblastoma	2.24	P = 10E − 15	81
VEGFA	Malignant glioma, NOS	210.500	P = 0.005	10	Pomeroy Brain/2002 [28]
	Glioblastoma	9.415	P = 1.03E − 6	26	Bredel Brain 2/2005 [39]
	Glioblastoma	8.624	P = 1.51E − 19	81	Sun Brain/2006 [36]
	Anaplastic astrocytoma	2.008	P = 0.003	19
	Pilocytic astrocytoma	7.651	P = 0.001	8	Guttman
	Glioblastoma	5.228	P = 5.10E − 4	30	Liang Brain/2005 [40]
	Glioblastoma	4.998	P = 5.28E − 8	27	Shai Brain/2003 [37]
	Anaplastic oligoastrocytoma	4.438	P = 0.003	23	French Brain/2005 [27]
	Anaplastic oligodendroglioma	3.121	P = 7.92E − 6	4
MMP2	Glioblastoma	6.426	P = 5.41E − 4	27	Bredel Brain 2/2005 [39]
	Glioblastoma	4.537	P = 0.003	30	Liang Brain/2005 [40]
	Pilocytic astrocytoma	4.030	P = 0.001	8	Gutmann Brain/2002 [41]
	Glioblastoma	3.548	P = 7.99E − 16	81	Sun Brain/2006 [36]
	Diffuse astrocytoma	3.342	P = 0.010	19
	Anaplastic astrocytoma	2.697	P = 1.33E − 5	7
	Anaplastic oligodendroglioma	2.980	P = 1.29E − 7	23	French Brain/2005 [27]
	Anaplastic oligoastrocytom	2.214	P = 0.006	4
NEDD9	Atypical teratoid/rhabdoid tumour	58.972	P = 0.008	5	Pomeroy Brain/2002 [28]
	Malignant glioma, NOS	17.133	P = 0.007	10
	Classic medulloblastoma	7.818	P = 3.59E − 8	46
	Desmoplastic medulloblastoma	5.238	P = 0.003	14
	Glioblastoma	2.330	P = 3.69E − 7	25	Bredel Brain 2/2005 [39]
HIF1A	Oligodendroglioma	3.395	P = 0.007	3	Shai Brain/2003 [37]
	Glioblastoma	2.660	P = 1.96E − 10	27
	Anaplastic oligoastrocytoma	3.101	P = 9.50E − 4	4	French Brain/2005 [27]
	Anaplastic oligodendroglioma	2.576	P = 4.35E − 6	23
	Glioblastoma	2.954	P = 5.21E − 9	26	Bredel Brain 2/2005 [39]
	Anaplastic oligodendroglioma	2.404	P = 4.78E − 4	3
	Oligodendroglioma	2.167	P = 0.003	5
	Diffuse astrocytoma	2.115	P = 6.68E − 5	7	Sun Brain/2006 [36]
	Astrocytoma	2.057	P = 5.79E − 4	45	Rickman Brain/2001 [38]