Table 2.
Proinflammatory effects of n-6 fatty-acid-derived eicosanoids and anti-inflammatory effects of the n-3 fatty-acid-derived eicosanoids.
| Proinflammatory effects of the n-6 fatty-acid-derived eicosanoids | |||
|
| |||
| Arachidonic acid (n-6) derived eicosanoids | Physiological effects | Organs or cells | |
|
| |||
| Prostaglandins | PGD2 | Bronchoconstriction Proinflammatory | Bronchi Activation of eosinophils |
| PGE2 | Proarrhythmic Induces fever Causes pain Increases production of IL-6 |
Vessels Nociceptor sensory neurons |
|
| PGF2 | Bronchoconstriction | Bronchi | |
| PGI2 | Proarrhythmic | Vessels | |
| Causes pain | Nociceptor sensory neurons | ||
|
| |||
| Thromboxanes | TXA2 | Proaggregation Vasoconstriction Bronchoconstriction |
Platelets Vessels Bronchi |
| TXB2 | Proaggregation Vasoconstriction Bronchoconstriction |
Platelets Vessels Bronchi |
|
|
| |||
| Leukotrienes | LTA4 | ||
| LTB4 | Proinflammatory Chemotaxis Release of reactive oxygen species |
Leukocytes Leukocytes Granulocytes |
|
| LTC4 | |||
| LTD4 | |||
| LTE4 | |||
|
| |||
| Anti-inflammatory effects of the n-3 fatty-acid-derived eicosanoids | |||
|
| |||
| EPA and DHA (n-3) derived eicosanoids | Physiological effects | Organs or cells | |
|
| |||
| Prostaglandins | PGD3 | ||
| PGE3 | Antiarrhythmic | Vessels | |
| PGF3 | |||
| PGI3 | Antiarrhythmic | Vessels | |
|
| |||
| Thromboxanes | TXA3 | Antiaggregation | Platelets |
| TXB3 | Antiaggregation | Platelets | |
|
| |||
| Leukotrienes | LTA5 | ||
| LTB5 | Anti-inflammatory | Leukocytes | |
| LTC5 | |||
| LTD5 | |||
| LTE5 | |||
|
| |||
| Resolvins | RVE1 | Antiaggregation Anti-inflammatory | Platelets Dendritic cells |
| RVD | Anti-inflammatory | ||
|
| |||
| Neuroprotectin | NPD1 | Anti-inflammatory Antiapoptotic Decreases oxidative stress |
Retina (photoreceptor cells) and brain |