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. Author manuscript; available in PMC: 2012 Apr 24.
Published in final edited form as: Nat Rev Neurosci. 2011 Mar;12(3):169–182. doi: 10.1038/nrn2995

Figure 4. Micro PET images of the head biodistribution of calcium channel blocker.

Figure 4

Micro PET images of the head of a Wistar rat, showing the biodistribution of the calcium channel blocker, [11C] verapamil injected systemically, either alone (Control) or after pre-treatment of the animal with the Pgp inhibitor Cyclosporin A. [11C] verapamil, a substrate for the blood-brain barrier efflux transporter P-glycoprotein, gains access to the brain only after Pgp inhibition by Cyclosporin A. Images are courtesy of Dr. P. Elsinga, University Medical Center Groningen, The Netherlands.