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. 2012 Feb 10;21(10):2194–2204. doi: 10.1093/hmg/dds034

Figure 2.

Figure 2.

Distinct molecular functions are associated with TBX20 activation and repression of transcription. (A) The log ratio of the abundance of functional categories (see Materials and Methods) between down- and up-regulated genes (RNA-seq data only). (B) The log ratio of the abundance of functional categories between genes with a nearby TBX20-binding region (putative TBX20 direct targets) that are down- and up-regulated (RNA-seq and ChIP-seq data combined). (C) Comparison of GO term fold-enrichment among (i) genes with a nearby TBX20 ChIP peak, (ii) all down-regulated, (iii) down-regulated with a nearby TBX20 ChIP peak (putative direct targets) and (iv) down-regulated genes with no nearby TBX20 ChIP peak (putative indirect targets). Arrows show instances in which enrichment is lower in direct targets than in indirect targets, suggesting that these categories are enriched for genes that are indirectly regulated in the absence of TBX20.