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. 2012 Feb 10;21(10):2194–2204. doi: 10.1093/hmg/dds034

Figure 4.

Figure 4.

Overlap of TBX20-binding regions with p300, GATA4, NKX2–5 and TBX5-binding regions. The set of genes with a nearby TBX20 ChIP-seq peak has different proportions of differentially expressed genes, compared with all genes (Fig. 1). Overlap of TBX20 ChIP peaks with (A) p300 (20), (B) GATA4, (C) NKX2–5 and (D) TBX5 (19) ChIP peaks further biases these proportions, suggesting that these proteins co-regulate gene expression with TBX20. X-axis: fold-difference between (i) the proportion of genes in a given expression category with a nearby TBX20 peak overlapping another ChIP peak and (ii) the proportion of genes in the same category with any nearby TBX20 peak (TBX20 only). Asterisks indicate statistically significant differences (P < 0.05), compared with TBX20 only. A description of the statistical test used is provided in Materials and Methods. Not expressed consists of the ‘no reads’ category. Results for the not expressed set with background levels were similar and are not shown for clarity sake (Supplementary Material, Fig. S6).