Table 4.
Mean pharmacokinetic parameters of Memantine in 20 healthy human volunteers after oral administration of 10 mg test and reference products.
| Pharmacokinetic details of Memantine in human plasma | ||
|---|---|---|
| Pharmacokinetic Parameter | Reference | Test |
| Mean ± SD | Mean ± SD | |
| C max (pg/ml) | 14368.57 ± 4044.16 | 14328 ± 4324.76 |
| AUC0−t (pg·hr/ml) | 654545.5 ± 70423.12 | 674564.4 ± 67858.99 |
| AUC0−∞ (pg·hr/ml) | 1053469.0 ± 77690.79 | 1136607 ± 74862.04 |
| T max (hr) | 7.0 | 7.5 |
| t 1/2 | 49.29 | 53.35 |
AUC0−∞: Area under the curve extrapolated to infinity.
AUC0−t: Area under the curve up to the last sampling time.
C max: The maximum plasma concentration.
T max: The time to reach peak concentration.