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Plasma and cerebral pharmacokinetic parameters after intraperitoneal administration of moxifloxacin (50 mg/kg) in infected and control mice (n = 6).
| T max (h) | C max | T 1/2 (h) | Cl (L/h) | Vd (L/kg) | AUC0-24h | |
|---|---|---|---|---|---|---|
| Plasma | (mg/L) | (mg·h/L) | ||||
| Infected | 0.75 | 17.3 ± 6.6 | 1.9 | 0.02 | 3.5 | 27.1 |
| Control | 1 | 6.7 ± 1.2 | 1.1 | 0.08 | 6.5 | 9.5 |
|
| ||||||
| Brain tissue | (μg/g of brain) | (μg·h/g of brain) | ||||
| Infected | 0.75 | 2.0 ± 0.2 | 21.7 | 3.3 | ||
| Control | 1 | 0.8 ± 0.3 | 10.7 | 1.0 | ||
