Table 1. Angiogenin variants identified by sequencing in US case/control series.
The association between common ANG variation and PD was evaluated using a logistic regression model adjusted for age (age at diagnosis for patients and age at blood draw for controls) and gender, where odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. We examined association under an additive model. For exploratory analysis P-values ≤ 0.05 were considered statistically significant and analyses were performed using PLINK (http://pngu.mgh.harvard.edu/purcell/plink/)
| Chromosome: BP | SNP | Amino Acid | major/minor allele | US Controls | US Cases | OR (95% CI) | p value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Major (%) | Het (%) | (%) | Total | MAF | Major (%) | Het (%) | Minor (%) | Total | MAF | ||||||
| 14:21152357 | rs117466368 | G/C | 643(95.1) | 33(4.9) | 0(0) | 676 | 0.024 | 600(95.2) | 30(4.8) | 0(0) | 630 | 0.024 | 0.87(0.52,1.46) | 0.60 | |
| 14:21152402 | rs117787610 | C/T | 652(96.4) | 24(3.6) | 0(0) | 676 | 0.018 | 608(96.5) | 22(3.5) | 0(0) | 630 | 0.017 | 0.87(0.48,1.59) | 0.66 | |
| 14:21152406 | rs117053048 | T/C | 642(95.0) | 34(5.0) | 0(0) | 676 | 0.025 | 600(95.2) | 30(4.8) | 0(0) | 630 | 0.024 | 0.85(0.51,1.42) | 0.53 | |
| 14:21152535 | rs45591635 | G/T | 644(95.3) | 31(4.6) | 1(0.1) | 676 | 0.024 | 599(95.1) | 31(4.9) | 0(0) | 630 | 0.025 | 0.91(0.55,1.51) | 0.72 | |
| 14:21152553 | rs113950902 | C/G | 676(100) | 0(0) | 0(0) | 676 | 0.000 | 629(99.8) | 1(0.2) | 0(0) | 630 | 0.001 | NA | NA | |
| 14:21152604 | rs28589507 | C/A | 531(78.6) | 128(18.9) | 17(2.5) | 676 | 0.120 | 497(78.9) | 124(19.7) | 9(1.4) | 630 | 0.113 | 0.92(0.72,1.16) | 0.47 | |
| 14:21152699 | rs45525731 | A/C | 646(95.6) | 30(4.4) | 0(0) | 676 | 0.022 | 600(95.2) | 30(4.8) | 0(0) | 630 | 0.024 | 0.95(0.56,1.61) | 0.85 | |
| 14:21152895 | rs117978329 | T/C | 644(95.3) | 32(4.7) | 0(0) | 676 | 0.024 | 600(95.2) | 30(4.8) | 0(0) | 630 | 0.024 | 0.89(0.53,1.5) | 0.66 | |
| 14:21152938 | IVS1+27 | C/T | 625(92.5) | 51(7.5) | 0(0) | 676 | 0.038 | 574(91.1) | 55(8.7) | 1(0.2) | 630 | 0.045 | 1.22(0.82,1.82) | 0.33 | |
| 14:21161794 | c.70G>C | A-1P | G/C | 676(100) | 0(0) | 0(0) | 676 | 0.000 | 629(98.8) | 1(0.2) | 0(0) | 630 | 0.001 | NA | NA |
| 14:21161844 | rs121909536 | K17I | A/T | 676(100) | 0(0) | 0(0) | 676 | 0.000 | 629(98.8) | 1(0.2) | 0(0) | 630 | 0.001 | NA | NA |
| 14:21161973 | rs17560 | K60E | A/G | 676(100) | 0(0) | 0(0) | 676 | 0.000 | 629(98.8) | 1(0.2) | 0(0) | 630 | 0.001 | NA | NA |
| 14:21162025 | c.302A>C | Q77P | A/C | 676(100) | 0(0) | 0(0) | 676 | 0.000 | 629(98.8) | 1(0.2) | 0(0) | 630 | 0.001 | NA | NA |
| 14:21162053 | rs11701 | T/G | 565(83.6) | 103(15.2) | 8(1.2) | 676 | 0.088 | 483(76.7) | 136(21.6) | 11(1.7) | 630 | 0.125 | 1.40(1.08,1.80) | 0.01 | |
| 14:21162248 | Exon2 + 81 | 3'UTR | A/C | 676(100) | 0(0) | 0(0) | 676 | 0.000 | 629(98.8) | 1(0.2) | 0(0) | 630 | 0.001 | NA | NA |