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. 2012 Apr 24;78(17):1354–1362. doi: 10.1212/WNL.0b013e3182518375

Figure 2. The social context network model (SCNM) and behavioral variant of frontotemporal dementia (bvFTD).

Figure 2

(A) The SCNM. Lateral view of the left hemisphere showing the proposed fronto-insular-temporal network (light blue, violet, and green regions of interest, respectively). In this context network, prefrontal areas (PFC) such as frontopolar and dorsolateral-prefrontal cortices would be involved in the generation of focused predictions via the update of associative activation of representations in the specific context. The insular cortex would provide the convergence point for emotional and cognitive states related to the coordination between external and internal milieus, facilitating the fronto-temporal interaction in social context processing. Finally, target-context associations stored in the temporal regions would be integrated with feature-based information processed in frontal regions. Connected nodes represent the fronto-insular-temporal interactions. (B) bvFTD atrophy pattern. Lateral view of earliest regions thought to be damaged in bvFTD, in the frontal, insular, and temporal areas (light blue, violet, and green regions of interest, respectively). Note the partial overlap with the nodes of the SCNM. Highlighted regions correspond to the following Brodmann areas: frontal (BA46, B10, BA11, BA24); temporal (BA20, BA21, BA38); and insula (BA48).