Table 4.
Viruses reported to bind to DISC1 interactome partners.
| DISC1 partner gene symbol | Protein name | Viral binder |
|---|---|---|
| ACTG1 | Actin, cytoplasmic 2 | HIV-1 [97] HSV1 [98] |
| ACTN2 | Actinin, alpha 2 | Hepatitis C [99] |
| AKAP9 | A-kinase anchor protein 9 | Epstein-Barr [97] |
| ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | HSV1 [98] |
| ATF5 | Cyclic AMP-dependent transcription factor ATF-5 | HTLV1 [100] |
| BICD1 | Protein bicaudal D homolog 1 | Cytomegalovirus [101] |
| C14orf135 | Uncharacterized protein C14orf135 precursor | Hepatitis C [102] |
| DCTN1 | Dynactin-1 | HSV1 [98] |
| DCTN2 | Dynactin subunit 2 | Dynactins are involved in the transport of the adenoviruses, HSV-1, the hantaan virus, HTLV-1 and the poliovirus [103–108] |
| DNAJC7 | DnaJ homolog subfamily C member 7 | Part of a complex forming the coxsackie virus receptor [109] |
| DYNC1H1 | Dynein heavy chain, cytosolic | Adenovirus (in a complex with dynactin and NDEL1) [110] |
| EEF2 | Elongation factor 2 | Epstein Barr [111] |
| EIF3S3 | Eukaryotic translation initiation factor 3 subunit 3 | Hepatitis C [112] |
| FEZ1 | Fasciculation and elongation protein zeta 1 (zygin I) | JC Polyomavirus [113] |
| HERC2 | HECT domain and RCC1-like domain-containing protein 2 | Papillomavirus 16 [114] |
| KIF3C | Kinesin-like protein KIF3C | HIV-1 [115] |
| MATR3 | Matrin-3 | HSV1 [98] |
| NDEL1 | Nuclear distribution protein nudE-like 1 | Part of a complex involved in Adenovirus transport (with dynactin and cytoplasmic dynein) [110] |
| PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha | Binds to Poliovirus P3 protein and HIV-1 Tat [116, 117] |
| PCNT | Pericentrin | Involved in the microtubular transport of the adenovirus [118] |
| PGK1 | Phosphoglycerate kinase 1 | Epstein-Barr [119] |
| SMARCE1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 | HSV-1 [97] |
| STX18 | Syntaxin-18 | Papillomavirus [119] |
| TNKS | Tankyrase-1 | Epstein-Barr [120] |
| TUBB | Tubulin beta chain | Epstein-Barr [119] |
| YWHAE | 14-3-3 protein epsilon | Hepatitis C [97] : L : Epstein-Barr [119] |
| YWHAQ | 14-3-3 protein theta | HIV [97] HSV1 [98] |
| YWHAZ | 14-3-3 protein zeta/delta | HSV1 [98] : Epstein-Barr [119] |