Table 1.
Chromosomal alterations and related molecular events in myxoid soft-tissue sarcomas.
| Tumor type | Chromosomal alteration | Molecular event | Prevalence |
|---|---|---|---|
| Myxoid/round cell liposarcoma | t(12; 16)(q13; p11) | FUS-DDIT3 | >90% |
| t(12; 22)(q13; q12) | EWSR1-DDIT3 | <5% | |
| Low-grade fibromyxoid sarcoma | t(7; 16)(q32–34; p11) | FUS-CREB3L2 | >95% |
| t(11; 16)(p11; p11) | FUS-CREB3L1 | <5% | |
| Extraskeletal myxoid chondrosarcoma | t(9; 22)(q22; q12) | EWSR1-NR4A3 | 75% |
| t(9; 17)(q22; q11) | TAF15-NR4A3 | 15% | |
| t(9; 15)(q22; q21) | TCF12-NR4A3 | <1% | |
| t(3; 9)(q12; q22) | TFG-NR4A3 | <1% | |
| Myxofibrosarcoma | Complex karyotype | Not known | Not applicable |
| Myxoinflammatory fibroblastic sarcoma | t(1; 10)(p22; q24) | Deregulation of FGF8 and NPM3 | Not applicable |
| Rearrangement of TGFBR3 and MGEA5 | Not applicable | ||
| Myxoid dermatofibrosarcoma protuberans | t(17; 22)(q22; q13)* | COL1A1-PDGFB | >90% |
*Rearrangement also frequently seen as a ring chromosome.