Figure 1. Overview of cutaneous defects in Msx2-Cre; KrasG12D mice.
(a) The 10-day-old and (b) 9-week-old Msx2-Cre; KrasG12D (KrasG12D) and control (wt) littermates demonstrate redundant skin and hair loss phenotypes. (c) Thickened eyelids and (d) shortened nails of Msx2-Cre; KrasG12D and wild-type littermate mice. Asterisk denotes abnormal short nail and arrowhead identifies coarse volar skin surface of Msx2-Cre; KrasG12D mice. (e) Papilloma on forepaw of Msx2-Cre; KrasG12D versus wild-type littermate. (f) Age of onset of progressive cutaneous phenotypes in Msx2-Cre; KrasG12D mice.