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. 2012 Apr 24;7(4):e35974. doi: 10.1371/journal.pone.0035974

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Data are shown as the average Shannon entropy in 30-aa acid windows with a one-residue step. Sequences are full-length with the three ORFs concatenated in head-to-tail fashion as ORF1, ORF2 and ORF3. Rubi (rubivirus), DQ085338; g1 (genotype 1), M80581; g2 (genotype 2), M74506; g3 (genotype 3), AB369691; g4 (genotype 4), AB220972; avian, AY535004. Subtype 3f sequences have a 27-aa sequence duplication removed from the PPR to allow better alignment of sequences. The PPRs are located by the grey arrow (avian HEV) and the black arrow (rubivirus and HEV genotypes 1, 3 and 4). The white arrow is immediately upstream from the rubivirus endopeptidase (centered near residue 1010).