Table 3. Genome-wide significant cis-eQTL for gluteus medius expression traits whose target genes are functionally related to lipid metabolism and fat deposition.
eQTL location and significance | QTL positional concordance in the same population | ||||
Cis-regulated Gene | Chromosome | Position | F-value | Nominal P-value | Linked Trait1 |
SNX14 | SSC01 | 28 cM | 4.81 | 0.000533 | - |
FIG4 | SSC01 | 40 cM | 5.10 | 0.000316 | - |
NEDD4L | SSC01 | 64 cM | 5.03 | 0.000359 | IMF |
EHD1 | SSC02 | 122 cM | 6.16 | 0.000048 | - |
ABAT | SSC03 | 10 cM | 5.62 | 0.000125 | IMF; Vaccenic FA |
GSPT1 | SSC03 | 10 cM | 5.60 | 0.000129 | IMF; Vaccenic FA |
LCMT1 | SSC03 | 24 cM | 7.78 | 0.000003 | IMF |
MEPCE | SSC03 | 24 cM | 5.15 | 0.000289 | IMF |
PPP1CB | SSC03 | 24 cM | 4.64 | 0.000725 | IMF |
APOBEC1 | SSC05 | 124 cM | 4.95 | 0.000414 | - |
PAFAH1B3 | SSC06 | 70 cM | 5.00 | 0.000379 | Vaccenic FA |
IL12RB2 | SSC06 | 92 cM | 5.13 | 0.000300 | IMF |
SLA-1 | SSC07 | 72 cM | 5.35 | 0.000202 | Palmitoleic FA |
NUDT6 | SSC08 | 76 cM | 6.94 | 0.000012 | Myristic FA |
ACER3 | SSC09 | 138 cM | 4.68 | 0.000675 | - |
ANXA8L1 | SSC14 | 44 cM | 4.78 | 0.000563 | Palmitoleic FA |
ITGAV | SSC15 | 68 cM | 4.56 | 0.000838 | MUFA; PUFA |
DNAJB6 | SSC18 | 40 cM | 4.98 | 0.000393 | Palmitic FA; SFA |
HOXA10 | SSC18 | 40 cM | 4.68 | 0.000675 | Palmitic FA; SFA |
IMF – intramuscular fat content; FA – Fatty Acid content (%); SFA – % saturated fatty acids; MUFA – % monounsaturated fatty acids; PUFA – % polyunsaturated fatty acids.